The storm, which hit southwestern Mexico as a Category 3 hurricane this week, is again threatening parts of the country’s Pacific Coast, this time as a Category 1.

Available antipsychotic treatments work by blocking dopamine receptors. The new drug, Cobenfy, takes a different approach.

Gov. Gavin Newsom signed several bills intended to atone for the state’s role in the oppression of Black Americans, but California legislators so far have sidelined proposals on cash reparations.

In his 2016 memoir, Senator JD Vance of Ohio described a rough childhood owing to his mother’s devastating drug addiction. Today, he and his mother, Beverly Aikins, are a remarkable team.

The surge could be 15 to 20 feet higher than normal tide levels, flooding dozens of communities along the Gulf Coast.

The British author of dozens of literary works has denied the allegations that five women made against him on a podcast series.

Why some billionaires are helping to promote political extremism.

The police in the small city of Lexington, Miss., routinely made unjustified arrests, used excessive force and trampled on civil rights, investigators said.

Intelligence agencies concluded that granting Ukraine’s request to use Western missiles against targets deep in Russia could prompt forceful retaliation while not fundamentally changing the course of the war.

Intelligence agencies concluded that granting Ukraine’s request to use Western missiles against targets deep in Russia could prompt forceful retaliation while not fundamentally changing the course of the war.

The federal indictment reveals how the city’s leader repeatedly failed in his duty to uphold the public trust.

The bill averts a campaign-season shutdown but ensures another spending fight in Congress during its lame-duck session in December.

The F.B.I. is also investigating the large chain of psychiatric hospitals for holding patients longer than what is medically necessary.

The region has endured two other hurricanes recently, but many more people appeared to be evacuating this time, leaving their small coastal towns eerily empty.

Also, Hurricane Helene heads toward Florida. Here’s the latest at the end of Thursday.

Jury selection in the case began on Thursday morning, and the trial had been expected to take up to four weeks.

You have to go way back to the days of the secular saint Fiorello La Guardia to come up with a New York mayor unencumbered by significant baggage.

As the war drags on, Ukraine’s president receives a quieter welcome in Washington and faces angry questions from some Republicans.

U.S. officials are stepping up their warnings about foreign interference in the election, focused on three main adversaries: Russia, China and Iran.

Health experts, gathering at the U.N., have begun to shift their focus to try to provide access to basic drugs in countries where preventable deaths from infections occur too frequently.